We want to seamlessly process and summarize metagenomics data from Illumina or Nanopore technologies. We built a Nextflow workflow that handles common metagenomics tasks and produces useful outputs and intuitive visualizations.
Rachel J. Dutton, Elizabeth A. McDaniel, and Manon Morin
RD
MM
DS
Published: Aug 15, 2023
Hoping to find proteins that alter physiology in useful ways, we screened venom data sets for toxins fused to domains with additional functionality. We identified candidates, but struggled to infer any novel functions, and none seem well-conserved across venomous species.
Prachee Avasthi, Brae M. Bigge, Feridun Mert Celebi, Keith Cheveralls, Jase Gehring, Erin McGeever, Gilad Mishne, Atanas Radkov, and 1 more
BB
KC
RD
+14
Published: Sep 29, 2023
The ProteinCartography pipeline identifies proteins related to a query protein using sequence- and structure-based searches, compares all protein structures, and creates a navigable map that can be used to look at protein relationships and make hypotheses about function.
Prachee Avasthi, Brae M. Bigge, Ilya Kolb, David G. Mets, Manon Morin, Austin H. Patton, and Ryan York
BB
IK
DM
+5
Published: Mar 06, 2024
We outline a comparative approach to investigate protein function by correlating the presence or absence of a protein with species-level phenotypes. We applied this strategy to a novel actin isoform in fungi but didn’t find an association with any of the phenotypes we considered.
We assembled a comprehensive E. coli antimicrobial resistance phenotype-genotype resource. This dataset will aid large-scale genetic studies on anti-microbial resistance and support research in phylogenetics and other fields.