On this page, we’re generating a library of the projects, technologies, and workflows that have been paused, or “put on ice,” at Arcadia.
Learning is an important part of science. If we’re doing it right, not everything we attempt will work out the way we expect. And in each of those cases, there is a lesson to capture.
Iced projects often yield data and insights that could be useful to others. We're committed to wrapping up these efforts by releasing associated pubs. By clearly delineating why certain efforts get the cold shoulder, we hope others can take full advantage of our exploration.
In some cases, the reasons for pausing may be addressable in the future or by others outside of Arcadia. We sincerely hope you take up the mantle — in fact, let us know if there’s anything we can do the help.
For more info on the Icebox and reasons that we may ice a project, read our blog post on the topic.
To make an impactful advancement, we’d need further technological or conceptual development.
We learned what we needed to learn from the project and there is no reason to continue.
We tried to derisk a project, but could not overcome barriers that would enable us to move forward, or our hypothesis was wrong in a way that the remaining possibilities are not of interest for us to pursue.
The project can’t be done without massive resources, it’s inefficient, or we don’t have a high-throughput approach to scan enough search space and have confidence we’ll be successful.
We've decided not to pursue this area of science at the moment because it doesn't play to our unique strengths as a company.
What we discovered during the project lands us in an area where we lack internal expertise, or taking the project to the next step would require expertise we don’t have (yet).
The market is not appropriate, big enough, well-scoped enough, or is in an area where we are not well positioned as a company to have a competitive advantage. The time horizon to make this translationally actionable is too long or the challenges are too layered to align with translational goals.
We lack the facilities, equipment, or tangible resources to act on this project.
Browse all our iced pubs and projects.
Pubs are data-focused but also contain brief explanations of why we chose not to follow up.
Projects link to a narrative page that describes the project’s initial goals, progress (including associated pubs), and reasons for discontinuing.
Comparing gene expression across species based on protein structure
A capsid-based search recovers viral sequences from human brain sequencing data
Identifying candidate accessory domains by mining putative venom protein fusions
Putative horizontal gene transfer events point to candidate genes involved in cross-species neuromodulation
Project: Exploring bacteriophage nucleic acid chemistries
Isolation of a phage with an arabinosylated genome from a cheese microbial community
HiPR-FISH spatial mapping of cheese rind microbial communities
Project: Understanding the evolution of actin-binding proteins across diverse species
Inducing protoplast formation in Phaeodactylum tricornutum by silica deprivation, enzymatic treatment, or cytoskeletal inhibition
Challenges of isolating bacteriophage mRNA for chemical analysis
Paired long- and short-read metagenomics of cheese rind microbial communities at multiple time points
A workflow to isolate phage DNA and identify nucleosides by HPLC and mass spectrometry
Chlorarachniophytes form light- and Arp2/3 complex-dependent extensions that are involved in motility and predation
Project: Dissecting mechanisms of environmental adaptation in protists
Project: Spatial genomics: Tracking biomolecules across space and time